refractory epilepsy prevalence

Results: Epilepsia. They may also have injuriesthat result from their seizures. They may worry alot about when their next seizure will come. 2020 Nov 13;10(11):856. doi: 10.3390/brainsci10110856. Please enable it to take advantage of the complete set of features! NLM HHS Online ahead of print. Epub 2016 Dec 27. Charupanit K, Sen-Gupta I, Lin JJ, Lopour BA. Epub 2014 May 13. Risk factors for drug-resistant epilepsy: A systematic review and meta-analysis. Epilepsy Behav Rep. 2020 Sep 2;14:100390. doi: 10.1016/j.ebr.2020.100390. eCollection 2020 Sep. Alcala-Zermeno JL, Gregg NM, Van Gompel JJ, Stead M, Worrell GA, Lundstrom BN. Clipboard, Search History, and several other advanced features are temporarily unavailable. The incidence of refractory epilepsy remains high despite the influx of many new antiepileptic drugs (AEDs) over the past 10 years. 2020 May 20;5(2):263-273. doi: 10.1002/epi4.12397. 2014 Sep;108(7):1253-62. doi: 10.1016/j.eplepsyres.2014.05.005. 1,2 Think of a school with 1,000 students—this means about 6 of them could have epilepsy. Prevalence of drug resistant epilepsy in adults with epilepsy attending a neurology clinic of a tertiary referral hospital in Singapore. Get the latest public health information from CDC: https://www.coronavirus.gov. Get the latest research from NIH: https://www.nih.gov/coronavirus. Cortical and thalamic electrode implant followed by temporary continuous subthreshold stimulation yields long-term seizure freedom: A case report. There are limited high-quality data available on DRE. 2005 Jun;46(6):858-77. doi: 10.1111/j.1528-1167.2005.54904.x. Epub 2018 Oct 2. Epidemiological data indicate that 20-40% of the patients with newly diagnosed epilepsy will become refractory to treatment. 2009;62(2):65-71. doi: 10.1159/000222775. An incorrect diagnosis of epilepsy, going to the wrong house, is more common than most people might think. NLM Epilepsia Open. In 2015, 1.2% of the US population had active epilepsy (95% CI* = 1.1-1.4). The pooled prevalence proportion of DRE among epilepsy patients was 0.30 (95% confidence interval [CI] 0.19-0.42), and the pooled incidence proportion was 0.15 (95% CI 0.11-0.19).  |  The pooled prevalence proportion of DRE among epilepsy patients was 0.30 (95% confidence interval [CI] 0.19-0.42), and the pooled incidence proportion was 0.15 (95% CI 0.11-0.19). Objective: Wiley Periodicals, Inc. © 2018 International League Against Epilepsy. HHS drug resistant; epidemiology; epilepsy; frequency; review; risk. MEDLINE and EMBASE were searched for observational studies of DRE published between January 1980 and July 2015. Get the latest public health information from CDC: https://www.coronavirus.gov. eCollection 2020. Zavala-Tecuapetla C, Cuellar-Herrera M, Luna-Munguia H. Int J Mol Sci. This is about 3.4 million people with epilepsy nationwide: 3 million adults and 470,000 children.Find the prevalence estimates for your state in the data table below. Mihály I, Orbán-Kis K, Gáll Z, Berki ÁJ, Bod RB, Szilágyi T. Brain Sci. Refractory epilepsy can have a big effect on your life. Multivariable prediction model of drug resistance in adult patients with generalized epilepsy from Colombia: A case-control study. 2017 Mar;99:662-666. doi: 10.1016/j.wneu.2016.12.074. The potential of pharmacogenetics in the treatment of epilepsy. Eur Neurol. Clipboard, Search History, and several other advanced features are temporarily unavailable. Please enable it to take advantage of the complete set of features!  |  1 Stevelink et al found an unexpectedly high prevalence of refractoriness in JME (35%) based on all seizure types (i.e., absence, myoclonic, and generalized tonic-clonic seizures). Epidemiological data indicate that 20-40% of the patients with newly diagnosed epilepsy will become refractory to treatment. Semprino M, Fasulo L, Fortini S, Martorell Molina CI, González L, Ramos PA, Martínez C, Caraballo R. Epilepsy Behav. This site needs JavaScript to work properly. Low-frequency Stimulation Decreases Hyperexcitability Through Adenosine A1 Receptors in the Hippocampus of Kindled Rats. 2019 Jul;98(30):e16402. Thirty-five studies met inclusion criteria, including 13 080 epilepsy patients and 3941 patients with DRE. doi: 10.1097/MD.0000000000016402. 1 This is about 3.4 million people with epilepsy nationwide: 3 million adults and 470,000 children. Get the latest research from NIH: https://www.nih.gov/coronavirus. An estimation of global volume of surgically treatable epilepsy based on a systematic review and meta-analysis of epilepsy.  |  Animal Model Exp Med. 2 Overall, it has been assumed that JME responds well to AEDs. This prevalence of refractoriness affecting one-third of people with … The definition of DRE varied widely across studies, with only 12% meeting the requirements of the ILAE definition. The number of people with epilepsy, using prevalence numbers, ranges from 1.3 million to 2.8 million (or 5 to 8.4 for every 1,000 people). USA.gov. Active Epilepsy a. NCI CPTC Antibody Characterization Program. Keywords: 2020 Nov;112:107493. doi: 10.1016/j.yebeh.2020.107493.  |  Quantifying the response to antiepileptic drugs: effect of past treatment history. Prevalence and Incidence of Drug-Resistant Mesial Temporal Lobe Epilepsy in the United States. Orozco-Hernández JP, Quintero-Moreno JF, Marín-Medina DS, Valencia-Vásquez A, Villada HC, Lizcano A, Martínez JW. 2007;48 Suppl 1:14-8. doi: 10.1111/j.1528-1167.2007.00994.x. 2020 Aug 3;3(3):245-255. doi: 10.1002/ame2.12131. 2018 Nov;88:176-180. doi: 10.1016/j.yebeh.2018.09.025. One chart review study by Smith and colleagues in England found that 13% of patients referred for refractory epilepsy did not have epilepsy. J Neurosurg. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. World Neurosurg. Basic Clin Neurosci. Epilepsy Res. 2006 Mar;10(2):57-65. doi: 10.1016/j.ejpn.2005.11.009. JME is a heterogenous disorder in which the prognoses have not been entirely clear. Epub 2020 Oct 3. Refractory epilepsy: a clinically oriented review. Demuru M, Kalitzin S, Zweiphenning W, van Blooijs D, Van't Klooster M, Van Eijsden P, Leijten F, Zijlmans M; RESPect Group. Epilepsy Behav. Plasticity of antiepileptic drug targets. Pharmacokinetic, pharmacodynamic, and neurochemical investigations of lamotrigine-pentylenetetrazole kindled mice to ascertain it as a reliable model for clinical drug-resistant epilepsy. The definition of drug-resistant epilepsy (DRE) affects case identification and treatment, and impacts prevalence or incidence estimates and health burden estimation in epidemiology. Epub 2006 Mar 10. COVID-19 is an emerging, rapidly evolving situation. 2020 Nov 13;21(22):8573. doi: 10.3390/ijms21228573. Int J Mol Sci. Lack of consistency in definitions limits the ability to obtain robust estimates on the burden of DRE. Pharmacogeneticists are currently attempting to understand the genetic basis of refractory epilepsy so that they can identify subgroups of patients who share a common genetic background and then target drug therapies to meet their specific needs. More data based on the ILAE definition from well-designed epidemiologic studies are needed to generate accurate and reliable results. Detection of anomalous high-frequency events in human intracranial EEG. Since individuals with refractory epilepsy do not share a common reason for their treatment resistance, the use of targeted drug therapies may be our best option for improving treatment outcomes in this patient population. 2020 May-Jun;11(3):333-347. doi: 10.32598/bcn.11.2.1713.1. 1. Epub 2009 Jun 12. This site needs JavaScript to work properly. If your doctor thinks you have refractoryepilepsy, he or she may suggest that you visit a medical center thatspecializes in epilepsy. Random-effect model meta-analyses were used to generate pooled estimates of prevalence or incidence and pooled odds ratios of the association with risk factors. The incidence of refractory epilepsy remains high despite the influx of many new antiepileptic drugs (AEDs) over the past 10 years. BMB Rep. 2020 Apr;53(4):234-239. doi: 10.5483/BMBRep.2020.53.4.002. USA.gov. People withrefractory epilepsy may have trouble at work or school. Asadi-Pooya AA, Stewart GR, Abrams DJ, Sharan A. Eur J Paediatr Neurol. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. 2020 Aug 18;21(16):5921. doi: 10.3390/ijms21165921. The definitions of DRE in these studies were compared with the definition in the ILAE guidelines. Epilepsy Prevalence in the United States. Treatment resistance is, therefore, a multifaceted phenomenon. In 2015, 1.2% of the total US population had active epilepsy. Sci Rep. 2020 Sep 4;10(1):14654. doi: 10.1038/s41598-020-71359-2. Epub 2020 May 1. The definition of DRE varied widely across studies, with only 12% meeting the requirements of the ILAE definition. Vaughan KA, Lopez Ramos C, Buch VP, Mekary RA, Amundson JR, Shah M, Rattani A, Dewan MC, Park KB. According to the latest estimates, about 0.6% of children aged 0-17 years have active epilepsy. NIH The value of intra-operative electrographic biomarkers for tailoring during epilepsy surgery: from group-level to patient-level analysis.  |  2018 Sep 1:1-15. doi: 10.3171/2018.3.JNS171722. Insights into Potential Targets for Therapeutic Intervention in Epilepsy. Age at onset, symptomatic epilepsy, abnormal neuroimaging findings, abnormal electroencephalography results, history of mental retardation, neuropsychiatric disorders, febrile seizure, and status epilepticus increased risk for DRE. 2008 Jan 1;70(1):54-65. doi: 10.1212/01.wnl.0000286959.22040.6e. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Altered expression of parvalbumin immunoreactivity in rat main olfactory bulb following pilocarpine-induced status epilepticus. Telemedicine, drug-resistant epilepsy, and ketogenic dietary therapies: A patient survey of a pediatric remote-care program during the COVID-19 pandemic. COVID-19 is an emerging, rapidly evolving situation. Methods: The objective of this systematic review is to evaluate the consistency between definitions of DRE in the literature and the official definition in the International League Against Epilepsy (ILAE) guidelines, and to estimate the incidence, prevalence, and risk factors for DRE. These numbers vary depending on when the studies were done, who was included, and a host of other factors. NIH Epilepsia. Drug resistance in epilepsy: putative neurobiologic and clinical mechanisms. Significance: Refractory epilepsy displays three similar categories. Amygdala Low-Frequency Stimulation Reduces Pathological Phase-Amplitude Coupling in the Pilocarpine Model of Epilepsy. Xue-Ping W, Hai-Jiao W, Li-Na Z, Xu D, Ling L. Medicine (Baltimore). Factors that may be used to predict whether or not a patient will respond favorably to AED therapy include the type of epilepsy, underlying syndrome, etiology, and the patient's history of seizure frequency, density, and clustering. Environmental factors, such as trauma and prior drug exposure, and genetic factors that predetermine the rate of absorption, metabolism, and uptake of a drug by target tissue may also uniquely impact an individual and influence their response to AED therapy. Neurology.  |  P38 Regulates Kainic Acid-Induced Seizure and Neuronal Firing via Kv4.2 Phosphorylation. eCollection 2020 Jun. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error.

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